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对108例幽门螺杆菌阳性消化性溃疡随机分为两组：治疗组60例用奥美拉唑联用羟氨苄青霉素，对照组48例单用奥美拉唑治疗．结果，治疗组溃疡愈合率、幽门螺杆菌根除率、活动性胃炎消失率分别为95％、93．3％、95％显著优于对照组；12个月复查溃疡复发率、幽门螺杆菌检出率治疗组分别为13．3％和35％，显著低于对照组．说明，奥美拉唑联用羟氨苄青霉素治疗幽门螺杆菌阳性消化性溃疡的疗效明显优于单用奥美拉唑．
108 cases of Helicobacter pylori-positive peptic ulcer were randomly divided into two groups: 60 cases in the treatment group were treated with omeprazole combined with amoxicillin, and 48 cases in the control group were treated with omeprazole alone. Results: The healing rate of ulcer, the rate of eradication of Helicobacter pylori and the disappearance rate of active gastritis in the treatment group were 95%, 93.3% and 95% respectively, which were significantly better than those in the control group. The ulcer recurrence rate and Helicobacter pylori were detected in 12 months Rate of treatment group were 13.3% and 35%, significantly lower than the control group. That omeprazole combined with amoxicillin in the treatment of positive H. pylori peptic ulcer efficacy was significantly better than omeprazole alone.