胃的“细胞保护”一词是指通过中和或抑制胃酸分泌以外的机制防止胃粘膜损害。为证实有细胞保护,非抗分泌剂量的抗分泌药或非抗分泌药防护胃粘膜的作用能力必须在大体和组织学上得到显示。保护细胞不受损害大概由于间接的作用,其机制(粘液分泌、重碳酸盐分泌、血流等)尚未阐明,或许不包含对个体细胞的加强,但确实包含增强内在的胃粘膜防御机制。动物研究显示多种药物可提供这种保护效应,其中有一些在人类可加速溃疡愈合。但这并不说明产生保护效应的机制一定与加速溃疡愈合的机制相同。内源性和外源性前列腺素(PG)类的细胞保护效应已被深入研究。本文复习除PG类以外的具有细胞保护作用的药物。临床用药 The term “cytoprotection” of the stomach means preventing gastric mucosal damage by neutralizing or inhibiting mechanisms other than gastric acid secretion. To demonstrate cytoprotection, the ability of non-antisecretory doses of antisecretory or non-antisecretory drugs to protect the gastric mucosa must be demonstrated grossly and histologically. Its mechanism (mucus secretion, bicarbonate secretion, blood flow, etc.) is not yet elucidated, probably not because it is an indirect effect, and may not include an enhancement of an individual’s cells, but does include mechanisms that enhance the intrinsic gastric mucosal defense. Animal studies show that many drugs can provide this protective effect, some of which can accelerate ulcer healing in humans. However, this does not indicate that the mechanism that produces the protective effect must be the same as the mechanism that accelerates ulcer healing. Cytoprotective effects of endogenous and exogenous prostaglandins (PGs) have been studied in depth. This article reviews drugs that have cytoprotective effects other than PGs. Clinical medication