大部分细胞毒药物对肺的毒性是在临床应用若干年后才见报道(表1)。这些药物一般可分为四类,即抗生素,烷化剂,抗代谢类及其他。其中博莱霉素、马利兰和甲氨蝶呤出现肺毒性频率较其他药物为高,分别为 The toxicity of most cytotoxic drugs to the lungs was reported only after several years of clinical use (Table 1). These drugs generally fall into four categories, namely antibiotics, alkylating agents, antimetabolites and others. Bleomycin, Maryland and methotrexate pulmonary toxicity frequency higher than other drugs, respectively