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作者把溶酶体相关膜蛋白 1 ( L AMP- 1 )分选信号连接到 1 6型人乳头状瘤病毒的致癌蛋白 E7( HPV- 1 6 E7)抗原上 ,构建了嵌合体 Sig/E7/L AMP- 1 ,发现含此嵌合体的重组痘苗病毒 ( Vac- Sig/E7/LAMP- 1 ,V)和Sig/E7/L AMP- 1 DNA( D)均能诱生强烈的抗肿瘤免疫。为了确定这两种
The authors ligated the lysosome-associated membrane protein 1 (L AMP-1) sorting signal to the oncogenic protein E7 (HPV-16 E7) antigen of the 16 human papillomavirus to construct the chimeric Sig / E7 / L AMP-1, the recombinant vaccinia virus (Vac-Sig / E7 / LAMP-1, V) and Sig / E7 / L AMP- 1 DNA (D) containing this chimera were found to induce strong anti-tumor immunity. In order to determine both