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在毛细血管扩张共济失调(AT)的病人T细胞克隆中,发现14号染色体臂间倒位〔inv(14)〕的末端断裂。并定位在免疫球蛋白重链基因(14q32.3)的外侧。作者报告3例在细胞遗传学表现与ATT细胞克隆相同的14号染色体臂间倒位的T细胞淋巴瘤。此3例皆有相似的免疫表现型。Hecht等(1984)通过T细胞淋巴瘤细胞系SUP-T_1的高分辨染色体带的分析,已将14号染色体臂间倒位的断裂点定在14q11.2和14q32.3。这3例病人经细胞遗传和免疫的研究,也证实了inv(14)(p11.2 q32.3)。
In T cell clones of patients with telangiectasia, ataxia (AT), a terminal cleavage at the chromosome 14 arm [inv (14)] was found. And located outside the immunoglobulin heavy chain gene (14q32.3). The authors report 3 cases of T-cell lymphoma inversions on chromosome 14 on the same cytogenetics as ATT cell clones. All three cases had similar immunophenotype. Hecht et al. (1984) analyzed the high-resolution chromosomal bands of the T-cell lymphoma cell line SUP-T_1 by locating the breakpoint at 14q11.2 and 14q32.3 on the 14th chromosome. The cytogenetic and immunological studies of these 3 patients also confirmed inv (14) (p11.2 q32.3).