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目的了解泉州市耐多药肺结核(MDR-TB)可疑患者筛查情况,探讨发现策略。方法对2012—2014年所有涂片阳性的慢性排菌、初治和复治失败、复发、返回、初治2或3月末阳性者、部分病灶广泛的新患者的痰标本结核菌培养和药敏试验结果进行分析。结果 2012—2014年共筛查各类MDR-TB可疑者1314例,痰菌培养阳性971例(73.9%),阴性336例(25.6%),污染7例(0.5%);抗结核药敏试验949例中,有12.8%(121/949)确诊MDR-TB和广泛耐多药肺结核(XDR-TB),其中复治(61.9%)和初治(43.3%)失败患者确诊率较高,新患者确诊率较低(1.8%)。结论在资源和能力有限的情况下,优先选择对高危人群进行筛查,是适合泉州市的耐多药肺结核患者的筛查策略。
Objective To investigate the screening of suspicious patients with multidrug-resistant tuberculosis (MDR-TB) in Quanzhou and to explore the strategies for finding them. Methods For all the smear-positive chronic row bacteria from 2012 to 2014, the initial and retreatment failed, relapse and return, the newly diagnosed 2 or 3 end-stage sputum specimens were collected from sputum specimens with TB Test results for analysis. Results A total of 1314 suspected MDR-TB cases were screened in 2012-2014, 971 cases (73.9%) were positive for sputum culture, 336 cases (25.6%) were negative, and 7 cases were contaminated (0.5%). Anti-tuberculosis susceptibility test Of the 949 cases, 12.8% (121/949) were diagnosed as MDR-TB and XDR-TB, with a higher diagnosis rate of retreatment (61.9%) and initial treatment failure (43.3%), The patient diagnosis rate is low (1.8%). Conclusion Screening of high-risk population is the first choice in the limited resources and capacity, which is the screening strategy for multidrug-resistant tuberculosis patients in Quanzhou.