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目的:研究儿童癫痫相关的围产期高危因素。方法:随访16986例新生儿后期癫痫的患病情况,分为儿童癫痫组与非癫痫组,比较两组各项围产期高危因素,进行单因素与多因素统计分析。结果:随访期内儿童癫痫的发病例数为118例(6.95‰),癫痫的发病率在1岁以下的儿童最高(27.12%)。儿童癫痫的发生与孕周、高龄产妇、低出生体重、流产史、宫内窘迫、喂养方式、孕期感染、子痫、胎盘早剥、新生儿惊厥都有相关性,并且孕周、子痫和新生儿惊厥是儿童癫痫发生的独立危险因素。结论:儿童癫痫的发生与围产期高危因素密切相关,这对临床儿童癫痫的诊疗可能有提示作用。
Objective: To study the perinatal risk factors associated with epilepsy in children. Methods: The prevalence of epilepsy in 16986 newborn infants was followed up. The patients were divided into epilepsy group and non-epilepsy group. The perinatal risk factors were compared between the two groups. Univariate and multivariate statistical analyzes were performed. Results: The incidence of epilepsy in children was 118 cases (6.95%) during the follow-up period. The incidence of epilepsy was the highest in children under 1 year (27.12%). Epilepsy in children with gestational age, older mothers, low birth weight, history of miscarriage, intrauterine distress, feeding, pregnancy infection, eclampsia, placental abruption, neonatal convulsions are related, and gestational age, eclampsia and Neonatal convulsions are independent risk factors for epilepsy in children. Conclusion: The incidence of epilepsy in children is closely related to the risk factors of perinatal period, which may be a hint for the clinical diagnosis and treatment of epilepsy in children.