论文部分内容阅读
甲基强的松龙(MP)具有抗炎和免疫抑制作用。近年来,大剂量 MP 冲击疗法用于治疗严重肾脏病患者,以恢复肾小球滤过率,改善免疫复合物沉积以及减轻蛋白尿。虽然 MP 常规剂量口服时极少有盐皮质激素副作用,但冲击疗法的剂量有引起尿钠排泌受阻而致钠潴留的危险。为此,作者研究 MP 冲击疗法对肾脏病和胶原病患者肾功能的影响,并探讨 MP 冲击治疗是否会普遍导致一过性肾衰及其发生的特殊因素。
Methylprednisolone (MP) has anti-inflammatory and immunosuppressive effects. In recent years, high-dose MP shock therapy has been used to treat patients with severe kidney disease to restore glomerular filtration rate, improve immune complex deposition, and reduce proteinuria. Although the usual dose of oral MP when oral administration of mineralocorticoid side effects, but the impact of the dose of therapy has caused the obstruction of sodium secretion caused by the risk of sodium retention. To this end, the authors investigated the impact of MP shock therapy on renal function in patients with nephropathy and collagen disease and explored whether MP shock therapy generally causes transient renal failure and its specific causes.