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约50%的患者发生心脏骤停后给予心肺复苏术能恢复自主循环。然而,在复苏后期,仍有很多患者由于全脑缺血后神经元的损伤而死亡。因此,心脏骤停后恢复和保护脑功能是十分必要的。亚低温疗法是第一种应用于院外心脏骤停患者改善存活率和神经功能的治疗方法。除此之外,还有其他多种方法正在处于动物实验和临床试验的研究当中。主要有溶栓治疗、特殊灌注液治疗和抗凋亡药物。该文就心脏骤停后大脑的病理生理改变和脑复苏的不同治疗措施予以综述。
Cardiopulmonary resuscitation (CPR) can restore spontaneous circulation in about 50% of patients after cardiac arrest. However, in the late recovery phase, many patients still die of neuronal damage following global cerebral ischemia. Therefore, cardiac arrest and protection of brain function is very necessary. Mild hypothermia is the first treatment that has been used to improve survival and neurological function in out-of-hospital cardiac arrest patients. In addition, there are many other methods that are in the study of animal experiments and clinical trials. The main thrombolytic therapy, special perfusion solution and anti-apoptotic drugs. This article reviews the pathophysiological changes of the brain after cardiac arrest and the different treatment measures of cerebral resuscitation.