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目的：研究粘膜恶性淋巴瘤的构成与本质及临床病理特点。方法：收集４８例原发于胃肠、鼻腔、口咽、甲状腺与膀胱粘膜的恶性淋巴瘤。对其中４１例进行了免疫学标记。并对全部病例进行了形态学分型。结果：经典粘膜相关淋巴组织来源的恶性淋巴瘤（ＭＡＬＴ－ＭＬ）仅占全部病例的１／３。临床上粘膜恶性淋巴瘤的发病率男性明显多于女性，但男性平均发病年龄晚于女性。Ｂ细胞性总体预后优于Ｔ细胞性，小细胞性预后优于混合细胞性与大细胞性。结论：（１）确实存在胃肠粘膜假性淋巴瘤，但其中部分可能为ＭＡＬＴ－ＭＬ的早期阶段。（２）关于真性肠型恶性组织细胞增生症与肠粘膜原发Ｔ细胞淋巴瘤的关系有待近一步研究。（３）尚无法完全排除粘膜原发霍奇金病的存在。
Objective: To study the constitution, essence and clinical pathological features of mucosal malignant lymphoma. Methods: Forty-eight malignant lymphomas were collected from gastrointestinal, nasal, oropharyngeal, thyroid and bladder mucosa. 41 of them were immunologically labeled. All cases were morphologically classified. RESULTS: Classical mucosa-associated lymphoid tissue-derived malignant lymphoma (MALT-ML) accounted for only 1/3 of all cases. Clinically, the incidence of malignant lymphoma of the mucous membranes is significantly higher in males than females, but the average age of males is later than females. The overall prognosis of B-cell is better than that of T-cell, and the prognosis of small cell is better than that of mixed cell and large cell. Conclusions: (1) Gastrointestinal mucosa pseudo lymphoma does exist, but some of these may be early stages of MALT-ML. (2) The relationship between true intestinal malignant histiocytosis and intestinal mucosal primary T-cell lymphoma remains to be further studied. (3) The presence of mucosal primary Hodgkin’s disease cannot yet be completely ruled out.