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目的:探讨三阴性乳腺癌(triple negative breast cancer,TNBC)的临床病理特点,以及TNBC中突变型p53的表达及其意义。方法:回顾性分析195例乳腺癌病例,按雌激素受体、孕激素受体、人表皮生长因子受体2的表达分为TNBC组34例和对照组161例。检测TNBC组织中突变型p53的表达,分析其与TNBC临床病理特征及预后的关系。结果:TNBC组病人的复发转移率较高(29.4%比1.2%,P<0.001)、无病生存率显著低于对照组(52.9%比90.7%,P<0.001)。TNBC组突变型p53阳性表达率明显高于对照组(47.1%比22.4%,P<0.01),且突变型p53阳性表达与TNBC腋窝淋巴结转移有关(77.8%比36.0%,P<0.05)。结论:TNBC乳腺癌复发转移率高,无病生存率较低,预后较差。TNBC组织中突变型p53表达上调,其可作为TNBC重要的预后指标。
Objective: To investigate the clinicopathological features of triple negative breast cancer (TNBC) and the expression of mutant p53 in TNBC and its significance. Methods: A retrospective analysis of 195 cases of breast cancer cases, according to the expression of estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2 divided into TNBC group of 34 cases and control group of 161 cases. To detect the expression of mutant p53 in TNBC tissues, and to analyze its relationship with clinicopathological features and prognosis of TNBC. Results: The recurrence and metastasis rates of patients in TNBC group were higher than those in control group (29.4% vs 1.2%, P <0.001), and the disease-free survival rate was significantly lower in TNBC patients (52.9% vs 90.7%, P <0.001). The positive rate of mutant p53 in TNBC group was significantly higher than that in control group (47.1% vs 22.4%, P <0.01). The positive expression of mutant p53 was associated with axillary lymph node metastasis of TNBC (77.8% vs 36.0%, P <0.05). Conclusion: The recurrence and metastasis rate of TNBC breast cancer is low, the disease-free survival rate is low, the prognosis is poor. Mutant p53 expression is up-regulated in TNBC tissues, which may serve as an important prognostic indicator of TNBC.