论文部分内容阅读
目的 探讨肥胖儿童血清胰岛素水平与体脂分布、胰岛素抵抗及血脂的关系。方法 对 6 8例单纯性肥胖儿童依据空腹血胰岛素 (FINS)及空腹血糖 (FBG)水平分为高胰岛素血症组 (HIG) 4 3例和正常胰岛素组 (NIG)2 5例 ,测量FBG、胰岛素 (INS)、血脂 ,计算体重指数 (BMI)、腰臀比、稳态模型胰岛素抵抗指数 (HOMA IR)、敏感指数 (HOMA IAI)、胰岛细胞分泌功能 (HOMA IS)及葡萄糖、胰岛素曲线下面积 (AUCBG、AUCINS)。结果 (1)HIG组BMI、腰围、腰臀比、HOMA IR、HOMA IS、AUCINS明显高于NIG组 (P <0 0 5、0 0 1、0 0 0 1) ,HOMA IAI低于NIG组 (P <0 0 0 1) ;(2 )HIG组FINS与BMI、腰围、腰臀比、HOMA IR、HOMA IS、AUCINS成正相关 (r =0 316 ,0 32 4 ,0 4 6 4 ,0 835 ,0 5 99,0 5 2 5 ,P <0 0 5 ,0 0 5 ,0 0 1,0 0 0 1,0 0 0 1,0 0 0 1) ,与HOMA IAI成负相关(r =- 0 812 ,P <0 0 0 1) ;(3)两组FBG、AUCBG、血脂差异无显著性 (P >0 0 5 )。结论 高胰岛素血症肥胖患儿体内脂质沉积严重且脂肪分布异常 ,胰岛素抵抗更为严重 ,高胰岛素血症可能为肥胖产生的原因之一。
Objective To investigate the relationship between serum insulin level and body fat distribution, insulin resistance and blood lipids in obese children. Methods According to the fasting blood insulin (FINS) and fasting blood glucose (FBG), 48 children with simple obesity were divided into 43 cases of hyperinsulinemia group (HIG) and 25 cases of normal insulin group (NIG) INS, blood lipid, BMI, WHR, HOMA IR, HOMA IAI, HOMA IS and glucose, insulin curve Area (AUCBG, AUCINS). Results (1) The BMI, waist circumference, waist-to-hip ratio, HOMA IR, HOMA IS and AUCINS in HIG group were significantly higher than those in NIG group (P <0.05,0,01,0.01) (2) There was a positive correlation between FINS and BMI, waist circumference, waist-hip ratio, HOMA IR, HOMA IS and AUCINS in HIG group (r = 0 316, 0 32 4, 0 464, 0 835, 0 5 99,0 5 2 5, P <0 05, 0 0 5, 0 0 1 0 0 0 1 0 0 0 0 1 0 0 0 1), and negatively correlated with HOMA IAI (r = - 0 812, P <0.01). (3) There was no significant difference in FBG, AUCBG and blood lipid between the two groups (P> 0.05). Conclusion Hyperinsulinemia obese children with severe lipid deposition and fat distribution abnormalities, more severe insulin resistance, hyperinsulinemia may be one of the causes of obesity.