论文部分内容阅读
目的探讨肿瘤标记物联合智能染色(I-SCAN)内镜对早期胃癌的诊断价值。方法选取2012年2月至2016年2月间四川省遂宁市第一人民医院收治的90例早期胃癌患者及50例健康体检者,测定血清中CA199及CA242水平,使用I-SCAN胃镜对受试者进行观察,对各方法的敏感性、特异性、准确度、阳性预测值和阴性预测值进行分析。结果早期胃癌组患者血清中CA199和CA242水平为(85.38±7.38)U/ml和(30.32±3.18)U/ml,均明显高于健康组的(10.73±2.01)U/ml和(3.36±1.08)U/ml,差异均有统计学意义(均P<0.05)。肿瘤标记物联合智能染色内镜对早期胃癌患者诊断敏感性、准确度、阳性预测值和阴性预测值均显著高于单独肿瘤标记物CA199、CA242或智能染色内镜检测,特异度显著低于单独检测,差异均有统计学意义(均P<0.05)。I-SCAN技术可有效对比病灶毗连区正常黏膜与病灶区血管走形及病变黏膜功能,可有效呈现其黏膜特征,有效实现多通道多颜色对比。结论早期胃癌患者采用肿瘤标记物联合智能染色内镜进行检查,可显著提高临床诊断率和准确性,具有较高的临床应用价值。
Objective To investigate the diagnostic value of tumor marker combined with intelligent staining (I-SCAN) endoscopy in early gastric cancer. Methods Ninety patients with early gastric cancer and 50 healthy subjects who were admitted to the First People’s Hospital of Suining City, Sichuan Province from February 2012 to February 2016 were enrolled. Serum levels of CA199 and CA242 were measured. I-SCAN gastroscopy Were observed, the sensitivity of the method, specificity, accuracy, positive predictive value and negative predictive value were analyzed. Results The serum levels of CA199 and CA242 in patients with early gastric cancer were (85.38 ± 7.38) U / ml and (30.32 ± 3.18) U / ml, respectively, which were significantly higher than those in healthy controls (10.73 ± 2.01 U / ml and 3.36 ± 1.08 ) U / ml, the differences were statistically significant (all P <0.05). The diagnostic sensitivity, accuracy, positive predictive value and negative predictive value of tumor markers combined with intelligent staining endoscopy in patients with early gastric cancer were significantly higher than those of tumor markers CA199, CA242 or intelligent staining endoscopy, the specificity was significantly lower The differences were statistically significant (all P <0.05). The I-SCAN technique can effectively compare the vascular tracts and lesion mucosal function in the normal mucosa and lesion area adjacent to the lesion, which can effectively display mucosal features and effectively achieve multi-channel multi-color contrast. Conclusion Early gastric cancer patients with tumor markers combined with intelligent staining endoscopy can significantly improve the clinical diagnosis rate and accuracy, and has a high clinical value.