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休克时体内有去甲肾上腺素含量的变化,临床对α受体阻断剂治疗休克看法不一。本文研究失血性休克大鼠肠系膜微血管和淋巴管对去甲肾上腺素反应性的变化,探讨休克的微循环变化及其与去甲肾上腺素的关系。结果发现,失血性休克时微血管的口径收缩,休克初期淋巴管收缩分数增加,休克晚期淋巴管总收缩活性指数降低,同时微血管及淋巴管对去甲肾上腺素的反应性降低,这可能是晚期微循环障碍、休克失代偿的机制之一,为临床选择药物提供了理论根据。
There is norepinephrine changes in the body when there is shock, and there are different opinions on the treatment of shock by the α receptor antagonist in clinic. This article studies the mesenteric microvascular and lymphatic vessels in hemorrhagic shock rats to norepinephrine changes in response to changes in microcirculation and its relationship with norepinephrine. The results showed that the caliber of capillaries contracted during hemorrhagic shock increased, the fraction of lymphatic vessels in the early stage of shock increased, the index of total contraction of lymphatic vessels in shock decreased, and the responsiveness of capillaries and lymphatic vessels to norepinephrine decreased, which may be late stage micro Circulatory disorders, shock decompensation mechanism for the clinical choice of drugs provides a theoretical basis.