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目的 检测纤维连接蛋白(Fn)在急性心肌梗死(AMI)患者中的表达,并探讨其临床意义。方法 AMI 组12例,健康对照组13例。以流式细胞仪检测外周血血小板膜上Fn的表达,用酶联免疫法(ELISA)检测血浆Fn的水平。结果 AMI患者血小板膜上Fn表达为67.88±19.55%,高于正常对照组的14.35±5.31%,差异有显著性(P< 0.01);AMI患者血浆Fn水平为515.17±83.85 mg,/L,高于正常对照组的361.54±68.48 mg/L,差异有显著性(P< 0.01)。结论Fn可能参与了AMI患者动脉血栓的形成。
Objective To detect the expression of fibronectin (Fn) in patients with acute myocardial infarction (AMI) and to explore its clinical significance. Methods AMI group 12 cases, healthy control group 13 cases. The expression of Fn in peripheral blood platelet membrane was detected by flow cytometry, and the level of Fn in plasma was detected by enzyme-linked immunosorbent assay (ELISA). Results The Fn expression of platelet membrane in patients with AMI was 67.88 ± 19.55%, which was significantly higher than that of the control group (14.35 ± 5.31%, P <0.01). The Fn level of AMI patients was 515.17 ± 83.85 mg / L, 361.54 ± 68.48 mg / L in normal control group, the difference was significant (P <0.01). Conclusion Fn may be involved in the formation of arterial thrombosis in patients with AMI.