据文献报导,恶性淋巴瘤(ML)骨髓浸润活检阳性率为16～75％。但与临床和预后的联系尚无报导。作者首次探讨了骨髓病理组织学与临床预后的关系。病人和方法:非何杰金淋巴瘤(简称ML)678例,以多发性骨髓瘤(MM)220例作为比较,均为回顾性调查。常规法取骨髓组织,处理后行多种组织化学染色。运用电子计算机分析一些组织学和组织形态学指标及临床指标与病人预后的关系。结果:678例ML中有骨髓侵犯活检阳性者468例,占69％,其中低度恶性ML阳性率为77％,各种类型的阳性率有所不同;高度恶性ML26％;60例蕈样霉 According to reports in the literature, the positive rate of malignant lymphoma (ML) bone marrow infiltration biopsy is 16 to 75%. However, there have been no reports of clinical and prognostic links. The author first explored the relationship between bone marrow histopathology and clinical prognosis. Patients and Methods: 678 non-Hodgkin’s lymphoma (ML) patients and 220 multiple myeloma (MM) patients were included in the retrospective study. Bone marrow tissue was routinely taken and treated with various histochemical stains. Using computer to analyze the relationship between some histological and histomorphometric indicators and clinical indicators and patient prognosis. RESULTS: Of 678 cases of ML, there were 468 cases of bone marrow biopsy positive, accounting for 69%, of which the positive rate of low-grade ML was 77%, and the positive rates of various types were different; the high-grade ML26%; 60 cases of mycelium