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目的:观察大剂量激素冲击治疗以及联合小剂量血浆置换治疗重症肌无力的效果。方法;采用回顾性研究方法分析６７例患者用不同方法治疗的疗效,疗效判定用临床绝对评分和相对评分法,结果:各组治疗前后临床绝对评分有显著性差异,ｌ个月后,单用吡啶斯的明组、激素冲击治疗组、联合小剂量血浆置换组的相对评分分别为２７%、４８%、８１%。大剂量激素组、联合血浆置换组起效时间分别为２~３周、１~２周。结论:大剂量激素冲击治疗重症肌无力疗效肯定,如辅以小剂量血浆置换疗效更佳。
Objective: To observe the effect of high-dose hormonal shock therapy combined with low-dose plasma exchange in the treatment of myasthenia gravis. Methods: A retrospective study was conducted to analyze the curative effect of 67 patients treated by different methods. Clinical absolute score and relative score method were used to determine curative effect. Results: There was significant difference in clinical absolute score before and after treatment in each group. After 1 month, The relative scores of pyridostigmine group, hormone shock treatment group and combined low-dose plasma exchange group were 27%, 48% and 81% respectively. High-dose hormone group, combined with plasma exchange group onset time were 2 to 3 weeks, 1 to 2 weeks. Conclusion: The effect of high-dose hormonal shock treatment of myasthenia gravis is positive, such as small-dose plasma replacement with better efficacy.