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作者对50例早期胃癌和1例十二指肠溃疡胃切除标本的粘膜幽门螺旋菌(HP)的分布与检出情况进行了详细回顾性观察,部分病例进行了改良W-S及复红染色。结果:50例早期胃癌中HP检出率为62.0％,但癌组织中HP阴性,该菌主要存在于癌周病变粘膜以胃粘膜慢性炎症,特别是活动性慢性胃炎为多,HP量及密度与炎症程度有关;异型增生粘膜HP少见;HP不仅存在于粘膜浅层,也可侵入深部腺管,但和非癌病例胃粘膜相比,早期胃癌病例的HP明显少于前者。作者认为,HP与慢性胃炎有关,而与胃癌的发生可能没有直接病因学联系。
The authors retrospectively reviewed the distribution and detection of mucosal Helicobacter pylori (HP) in 50 cases of early gastric cancer and 1 case of duodenal ulcer gastrectomy specimens. In some cases, improved W-S and complex red staining were performed. RESULTS: The detection rate of HP in 50 cases of early gastric cancer was 62.0%, but HP was negative in cancer tissues. The bacteria mainly existed in the mucosa of the cancerous lesions with chronic inflammation of the gastric mucosa, especially active chronic gastritis, HP volume and density. It is related to the degree of inflammation; dysplasia HP is rare; HP is not only present in the superficial mucosa, but also can invade deep glands, but compared with non-cancerous gastric mucosa, the HP of early gastric cancer cases is significantly less than the former. The authors believe that HP is associated with chronic gastritis and may not have a direct etiologic link with the occurrence of gastric cancer.