论文部分内容阅读
OBJECTIVE A system was established to evaluate the metastasisand prognosis of oral squamous cell carcinoma by analyzing thetumor differentiation, the TNM stage, the mode of invasion, andthe expression of E-cadherin and S100A4.METHODS Squamous cell carcinoma of the oral cavityof 86 cases was the focus of our study. In this system, thehistopathological grade and the histochemical patterns wereestimated on a 0-3 point scale, the total points graded from 0 to 13.RESULTS The incidence of metastasis and prognosis in thecases with total points more than 8 was significantly higher thanthat with total points less than 7 (P < 0.05, x~2= 22.0658 and P < 0.05,x~2 = 10.7047). The system had a significant higher specificity thanthat of ‘DIAGS index’ system (Differentiation, Invasion mode,Adhesion molecules, Glycosaminoglycan, and the Sugar chain)in the evaluation of metastasis (P < 0.05, u = 2.2339). Moreover,the specificity for evaluation of metastasis in the system wassignificantly higher than that of E-cadherin (P < 0.05, u = 2.4996)or S100A4 (P < 0.05, u = 2.4289) only. Furthermore the specificityfor evaluation of unfavorable prognosis in the system was alsosignificantly higher than that of E-cadherin (P < 0.05, u = 2.1313) orS100A4 only (P < 0.05, u = 2.0301).CONCLUSION This is a valuable evaluation system with highspecificity to predict metastatic potential and prognosis of oralsquamous cell carcinoma.
OBJECTIVE A system was established to evaluate the metastasis and prognosis of oral squamous cell carcinoma by analyzing the tumor differentiation, the TNM stage, the mode of invasion, and the expression of E-cadherin and S100A4.METHODS Squamous cell carcinoma of the oral cavity of 86 cases was the focus of our study. In this system, thehistopathological grade and the histochemical patterns were estimated on a 0-3 point scale, the total points graded from 0 to 13.RESULTS The incidence of metastasis and prognosis in thecases with total points more than 8 was significantly higher thanthat with total points less than 7 (P <0.05, x ~ 2 = 22.0658 and P <0.05, x ~ 2 = 10.7047). The system had a significantly higher specificity thanthat ’DIAGS index’ system (Differentiation, Invasion mode, Adhesion molecules, Glycosaminoglycan, and the Sugar chain) in the evaluation of metastasis (P <0.05, u = 2.2339). Furthermore, the specificity for evaluation of metastasis in the system wassignificantly higher than that of E-cadherin (P <0.05, u = 2.4996) or S100A4 only. Furthermore the specificity for evaluation of unfavorable prognosis in the system was alsosificificarily higher than that of E-cadherin (P <0.05 , u = 2.1313) orS100A4 only (P <0.05, u = 2.0301) .CONCLUSION This is a valuable evaluation system with highspecificity to predict metastatic potential and prognosis of oralsquamous cell carcinoma.