论文部分内容阅读
霍乱是一种烈性肠道传染病,是我国传染病防治法规定的甲类传染病。国内外不少学者发现,菌毛与霍乱弧菌的黏附定居有关,其中甘露糖敏感血凝素(MSHA)属于Ⅳ型菌毛,决定Ⅳ型菌毛的血凝活性。MSHA为一免疫原,同时在霍乱弧菌在环境中存活方面起着特殊作用。主要由霍乱弧菌ElTor生物型和O139产生,古典生物型存在其结构基因mshA,但仅以极低水平表达并不产生MSHA。MSHA在霍乱弧菌疫苗及相关诊断试剂盒的研制方面有一定的实用价值。
Cholera is a potent intestinal infectious disease, which is a type A infectious disease stipulated by the Law of the People’s Republic of China on the Prevention and Treatment of Infectious Diseases. Many scholars at home and abroad have found that the fimbriae is related to the adhesion and colonization of Vibrio cholerae, of which mannose-sensitive hemagglutinin (MSHA) belongs to type IV pili and determines the hemagglutination activity of type IV pili. MSHA is an immunogen and plays a special role in the survival of Vibrio cholerae in the environment. It is mainly produced by Vibrio cholerae ElTor and O139. The classical biotype has its structural gene mshA, but it is not expressed at very low levels and does not produce MSHA. MSHA in the development of Vibrio cholera vaccine and related diagnostic kits have some practical value.