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目的探讨珊瑚甲硝唑复合人工骨植入智齿牙槽窝在修复邻近的第二磨牙远中牙周骨缺损和预防干槽症等方面的作用。方法根据随机设计和自体对照原则，对１１例要求拔除双侧下颌低位阻生智齿的患者，在一侧牙槽窝植入珊瑚甲硝唑，另一侧不植入任何材料作自体对照。在手术前后进行了临床和Ｘ线检查及邻近的第二磨牙远中颊侧牙龈附着丧失测定。结果术后１２周，材料植入组的牙槽窝骨缺损和牙槽嵴高度均得到良好的恢复，材料完全为宿主骨取代，邻近的第二磨牙远中颊侧的牙龈附着丧失明显小于术前（Ｐ＜０．０１），无１例出现干槽症；而对照侧的牙龈附着丧失与术前无显著差异，有１例出现干槽症。结论珊瑚甲硝唑植入智齿牙槽窝可较好地修复邻近的第二磨牙远中牙周骨缺损。但它对干槽症的预防作用尚有待于进一步研究证实。
Objective To investigate the role of coral metronidazole composite artificial bone implanted in wisdom tooth socket in repairing the second periodontal bone defects and preventing dry socket in the second molars. Methods According to the principle of random design and autologous control, 11 patients with mandibular lower impacted wisdom teeth were implanted with coral metronidazole on one side of the alveolar fossa, and no material was used as an autologous control on the other side. Clinical and radiographic examinations of the distal mid-buccal gingival attachment loss were performed before and after surgery. Results At 12 weeks after operation, the alveolar bone defect and height of alveolar ridge were recovered well and the material was completely replaced by the host bone. The loss of gingival attachment to the distal buccal side of the adjacent second molar was significantly less than that of the second molar (P <0.01). No case of dry socket was found in one case. However, the loss of gingival attachment on the control side was not significantly different from that of preoperative ones. One case had dry socket disease. Conclusion Implantation of coral metronidazole in the wisdom tooth socket can well repair the adjacent second molar distal periodontal defects. But its preventive effect on dry trough disease needs to be confirmed by further research.