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本文采用微小卫星多态性分析方法，对我国南方及北方鼻咽癌病人共18例在第三号染色体短管选取5个微小卫星标记位点进行分析。结果，18例中有5例肿瘤组织出现1个基因标记位点的等位基因丢失，1例全部5个位点均出现等位基因丢失，所有病人白细胞染色体中均未见等位基因丢失，杂合型丢失（LOH）频率分别为18.8％、6．6％、12．5％、12．5％和13．3％。结果表明，我国南北方鼻咽癌病人在分子遗传水平上无明显差别。本文选用的5个微星多态性基因标记，在鼻咽癌中无明确的特征性改变，但等位基因丢失只出现在肿瘤细胞染色体，而作为正常对照的其自身血液白细胞染色体均未出现丢失，因而仍在一定程度上反映了等位基因丢失与鼻咽癌的关系。
In this paper, using microsatellite polymorphism analysis method, 18 microsatellite loci were selected from the third chromosome short tube in 18 southern and northern nasopharyngeal cancer patients in our country. As a result, allele loss was found in one of the 18 cases of 5 tumor tissues, 1 case of allelic loss in all 5 loci, and none of the leukocyte chromosomes of all the patients were lost, Heterozygous loss (LOH) frequencies were 18.8%, 6.6%, 12.5%, 12.5% and 13.3%, respectively. The results showed that there was no significant difference in the molecular genetic level between NPC patients in our country and in the north. The five MSM markers selected in this study did not show any clear characteristic changes in NPC, but allelic loss only appeared in tumor cell chromosomes, but no loss in their own blood leukocyte chromosomes as normal controls , Thus still to some extent reflects the relationship between allelic loss and nasopharyngeal carcinoma.