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目的：探讨肿瘤坏死因子－α（ＴＮＦ－α）、内皮素（ＥＴ）、一氧化氮（ＮＯ）在急性脑梗塞发病中的作用。方法：采用放射免疫法和化学比色法测定了９３ 例急性脑梗塞各期患者和７６ 例健康人的外周血ＴＮＦ－α、ＥＴ、ＮＯ的含量水平。结果：脑梗塞急性期患者血中的ＴＮＦ－α、ＥＴ、ＮＯ含量明显高于稳定期和恢复期（Ｐ＜ ０．０５～０．００１），而稳定期和恢复期ＴＮＦ－α、ＥＴ 、ＮＯ均高于正常对照组（Ｐ＜ ０．０５～０．００１），并与脑梗塞的分期和严重程度相关，且在急性期ＴＮＦ－α与ＥＴ、ＮＯ呈正相关（ｒ分别为０．７５、０．７３）。结论：这些因子的升高不仅在急性期脑缺血性损伤，而且在缺血性脑卒中发病中可能起一定的作用
Objective: To investigate the role of tumor necrosis factor-α (TNF-α), endothelin (ET) and nitric oxide (NO) in the pathogenesis of acute cerebral infarction. Methods: The levels of TNF-α, ET and NO in peripheral blood of 93 acute cerebral infarction patients and 76 healthy volunteers were determined by radioimmunoassay and chemical colorimetry. Results: The levels of TNF-α, ET and NO in patients with acute cerebral infarction were significantly higher than those in stable and recovery stages (P <0.05-0.001) (P <0.05-0.001), and correlated with the stage and severity of cerebral infarction. There was a positive correlation between TNF-α and ET and NO in acute phase (r = 0.75 , 0.73). CONCLUSIONS: The elevation of these factors may play a role not only in acute ischemic brain damage but also in the pathogenesis of ischemic stroke