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目的:他汀类药物在治疗骨质疏松症时会加重肌肉损伤。本实验研究左卡尼汀和辅酶Q10对阿托伐他汀在切除卵巢的老鼠的抗骨质疏松作用的影响。创新点:研究新的治疗骨质疏松症及其并发症的方法。方法:选取48只雌性SD大鼠,40只大鼠切除卵巢,8只为假手术组。切除卵巢8周后,大鼠被分成去卵巢非治疗组和4个去卵巢治疗组(每组8只),通过灌胃法给药(单位为mg/(kg·d),为期8周):雌二醇(0.1)、阿托伐他汀(50)、阿托伐他汀(50)+左卡尼汀(100)或阿托伐他汀(50)+辅酶Q10(20)。在治疗结束时,测量骨矿物质密度、骨矿物质含量及骨代谢标志物和肌酸激酶的血清水平,利用股骨研究抗断强度和组织病理学变化。结论:相比辅酶Q10,合并给药左卡尼汀可在提高阿托伐他汀对切除卵巢的老鼠的抗骨质疏松作用的同时避免肌肉损伤。
Purpose: Statins increase muscle damage in the treatment of osteoporosis. This study was to investigate the effects of levocarnitine and coenzyme Q10 on the anti-osteoporosis effect of atorvastatin in ovariectomized mice. Innovative point: to study new ways to treat osteoporosis and its complications. Methods: Forty-eight female SD rats were selected, 40 were ovariectomized and 8 were sham-operated. After 8 weeks of ovariectomy, the rats were divided into ovariectomized non-treatment group and 4 ovariectomized treatment groups (8 in each group) and administered by gavage (in mg / (kg · d) for 8 weeks) : Estradiol (0.1), atorvastatin (50), atorvastatin (50) + levocarnitine (100) or atorvastatin (50) + coenzyme Q10 (20). At the end of treatment, bone mineral density, bone mineral content and serum levels of markers of bone metabolism and creatine kinase were measured, and the femur was used to study the intensity of resistance and histopathological changes. CONCLUSIONS: The combination of L-carnitine and coenzyme Q10 improves the anti-osteoporosis effect of atorvastatin on ovariectomized mice while avoiding muscle damage.