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目的探讨检测血清胱抑素C(Cys C)及24 h尿微量清蛋白(24 h U-m Alb)水平对诊断早期肾小球损伤疾病的影响。方法选取2014年6月至2014年12月抚顺矿务局总医院收治的50例慢性肾小球肾炎伴早期肾功能损伤患者作为观察组,选取来院健康体检的50例正常人作为对照组,采用免疫比浊法检测两组受检者的Cys C及24 h U-m Alb水平。结果观察组患者的血清Cys C、24 h U-m Alb水平均明显高于对照组,差异均有统计学意义(均P<0.05);观察组患者血清Cys C和24 h U-m Alb水平高于正常值的检出率均明显高于对照组,差异均有统计学意义(均P<0.05)。结论 Cys C及24 h U-m Alb在慢性肾小球肾炎伴肾功能损伤时明显升高,其可作为评估慢性肾小球肾炎患者早期肾功能损伤情况的敏感指标。
Objective To investigate the effects of detecting serum cystatin C (Cys C) and 24 h urine microalbumin (24 h U-m Alb) on the diagnosis of early glomerular injury. Methods Fifty patients with chronic glomerulonephritis with early renal impairment admitted from the General Hospital of Fushun Mining Bureau from June 2014 to December 2014 were selected as the observation group and 50 healthy individuals from the hospital were selected as the control group. Immunocytometry was used to detect Cys C and 24 h Um Alb levels in both groups. Results The levels of serum Cys C and 24 h Um Alb in the observation group were significantly higher than those in the control group (all P <0.05). The levels of serum Cys C and 24 h Um Alb in the observation group were significantly higher than those in the control group Were significantly higher than the control group, the difference was statistically significant (P <0.05). Conclusions Cys C and 24 h U-m Alb are significantly increased in patients with chronic glomerulonephritis associated with renal dysfunction, which can be used as a sensitive index to evaluate early renal injury in patients with chronic glomerulonephritis.