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胃粘膜肠上皮化生(简称肠化)的分型标准以及与胃癌的关系尚不统一,目前仍存争议。近年,国内外学者应用粮液组化方法将肠化分为不同的亚型来探讨肠化与胃癌的关系,多数认为含有硫酸粘液的不完全型肠化在胃癌的发生中有特殊意义。作者应用结肠卵巢肿瘤抗原(简称COTA),一种与肿瘤性结肠上皮细胞有关的粘液性抗原,对一组胃癌和各种不同病变的肠化组织作免疫组化染色,观察COTA在这些组织中的分布,探讨肠化与胃癌的关系。
The classification criteria of gastric mucosal intestinal metaplasia (referred to as intestinal metaplasia) and the relationship with gastric cancer are still not unified, and there is still controversy. In recent years, domestic and foreign scholars have applied the liquid-liquid method to classify intestinal metaplasia into different subtypes to investigate the relationship between intestinal metaplasia and gastric cancer. Most of them believe that incomplete intestinal metaplasia with sulphuric acid mucus is of special significance in the development of gastric cancer. The authors used colorectal ovarian tumor antigen (referred to as COTA), a mucin antigen associated with neoplastic colonic epithelial cells, and immunohistochemical staining of a group of gastric cancer and various lesions of intestinal metastases to observe COTA in these tissues The distribution, to explore the relationship between intestinal metastasis and gastric cancer.