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目的:探讨c-myc、hnRNPK蛋白在胃癌中的表达及意义。方法:采用SP免疫组织化学方法检测71例胃癌组织及71例对照胃组织中c-myc与hnRNPK的表达。结果:免疫组化显示胃癌组织hnRNPK阳性率为78.9%(56/71),高于非胃癌组织47.9%(34/71),P<0.01,并且在胞质、胞核均有表达。c-myc在胃腺癌中的阳性率为56.3%(40/71),与对照组相比,组间差异有统计学意义,P<0.01,且hnRNPK的表达与c-myc呈正相关(r=0.241,P<0.01)。以上两者在有淋巴结转移组均呈高表达,P<0.05。结论:c-myc、hnRNPK在胃腺癌组织中呈高表达,同时两者的表达呈正相关,有淋巴结转移组高于非转移组,提示hnRNPK参与了胃癌的发生及转移过程,其机制可能是通过激活c-myc基因而产生的。
Objective: To investigate the expression and significance of c-myc and hnRNPK in gastric cancer. Methods: The expressions of c-myc and hnRNPK in 71 gastric cancer tissues and 71 control gastric tissues were detected by SP immunohistochemistry. Results: Immunohistochemistry showed that the positive rate of hnRNPK was 78.9% (56/71) in gastric cancer tissues, which was significantly higher than that in non-gastric cancer tissues (47.9%, 34/71), P <0.01, and expressed in cytoplasm and nucleus. The positive rate of c-myc in gastric adenocarcinoma was 56.3% (40/71). There was significant difference between the two groups (P <0.01), and the expression of hnRNPK was positively correlated with c-myc (r = 0.241, P <0.01). The above two were highly expressed in lymph node metastasis group, P <0.05. Conclusions: The expression of c-myc and hnRNPK in gastric adenocarcinoma is high, and the expression of c-myc and hnRNPK is positively correlated with lymph node metastasis, which indicates that hnRNPK is involved in the carcinogenesis and metastasis of gastric carcinoma. The mechanism may be through Activation of c-myc gene generated.