地中海贫血(简称地贫)是一组慢性溶血性贫血,其发病机制是由于珠蛋白肽链合成出现障碍,造成肽链数量的不平衡而导致溶血性贫血。我国地贫的发病率为1.6%,广东地区是地中海贫血的高发区。轻型地贫一般不需治疗,对患者终生不造成严重影响。重型β-地贫对患者的生命构成威胁,不经治疗预后严重,患者多在5岁以前死亡,故重型β-地贫的治疗是当前 Thalassemia (thalassemia) is a group of chronic hemolytic anemia, its pathogenesis is due to obstacles in the synthesis of globin peptide chain, resulting in an imbalance in the number of peptide chains leading to hemolytic anemia. The incidence of thalassemia in China is 1.6%. Guangdong is a high incidence of thalassemia. Light Thalassemia generally does not require treatment and will not have a serious impact on the patient’s lifetime. Severe β-thalassemia in patients with life-threatening, without treatment, the prognosis is serious, the majority of patients died before the age of 5, so the treatment of severe β-thalassemia is currently