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目的研究乙型肝炎病毒e抗原(HBeAg)阳性慢性乙型肝炎患者红细胞天然免疫黏附功能(RNIAF)与血清可溶性Ⅰ型补体受体(sCR1)的浓度变化,分析二者的相关性,并探讨其临床意义。方法选择48例肝功能正常、血清HBV DNA大于106 U/mL的HBeAg阳性慢性乙型肝炎患者作为肝功能正常组,48例转氨酶高于正常值2倍以上的HBeAg阳性慢性乙型肝炎患者作为肝功能异常组。检测RNIAF,同时采用酶联免疫定量检测试剂盒测定血清sCR1含量。结果肝功能异常组的HBeAg阳性慢性乙型肝炎患者RNIAF较肝功能正常组及健康对照组显著下降,而sCR1含量显著升高,差异有统计学意义(P<0.01)。动态观察持续肝功能异常的HBeAg阳性慢性乙型肝炎患者RNIAF与血清sCR1含量变化,显示二者呈明显负相关(r=-0.91)。HBeAg阳性慢性乙型肝炎患者血清sCR1含量与凝血酶原活动度也呈明显负相关(r=-0.87)。结论 HBeAg阳性慢性乙型肝炎患者RNIAF与血清sCR1的含量变化与肝脏功能损伤严重程度密切相关,可作为临床判断肝病患者病情严重程度及预后的参考指标。
Objective To investigate the changes of erythrocyte innate immune adhesion function (RNIAF) and serum soluble type Ⅰ complement receptor (sCR1) in patients with hepatitis B virus e antigen (HBeAg) -positive chronic hepatitis B, and to analyze the relationship between them Clinical significance. Methods Forty-eight patients with HBeAg-positive chronic hepatitis B who had normal hepatic function and serum HBV DNA greater than 106 U / mL were enrolled as normal liver function patients and 48 patients with HBeAg-positive chronic hepatitis B whose transaminases were more than twice the normal value, Abnormal function group. RNIAF was detected, and the content of sCR1 in serum was detected by enzyme-linked immunosorbent assay kit. Results The RNIAF of HBeAg-positive chronic hepatitis B patients with abnormal liver function was significantly lower than that of normal liver function group and healthy control group, while the content of sCR1 was significantly increased (P <0.01). Dynamic observation of RNIAF and serum sCR1 levels in HBeAg-positive chronic hepatitis B patients with persistent abnormal liver function showed a significant negative correlation (r = -0.91). Serum sCR1 levels in patients with HBeAg-positive chronic hepatitis B were also significantly negatively correlated with activity of prothrombin (r = -0.87). Conclusion The changes of RNIAF and serum sCR1 levels in patients with HBeAg-positive chronic hepatitis B are closely related to the severity of liver injury, which may be used as a reference index for judging the severity and prognosis of patients with liver disease.