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目的探讨野菊花注射液在视网膜缺血再灌注损伤中对wt-p53的影响。方法纯种大耳白兔制作成兔视网膜缺血再灌注损伤动物模型,玻璃体腔注射平衡盐溶液(损伤组)和玻璃体腔注射野菊花注射液(治疗组),检测视网膜组织中的wt-p53的表达变化。结果缺血组和治疗组视网膜wt-p53阳性表达进行比较,差别有统计学意义(P<0.05)。结论提示视网膜缺血再灌注后早期玻璃体腔内注射野菊花注射液能够抑制wt-p53的表达。
Objective To investigate the effect of wild chrysanthemum injection on wt-p53 in retinal ischemia-reperfusion injury. Methods Rabbit models of rabbit retinal ischemia-reperfusion injury were made by the purebred rabbits. The balanced saline solution (intraperitoneal injection) and intravitreal injection of wild chrysanthemum injection (treated group) were made into vitreous cavity to detect the expression of wt-p53 Changes in expression. Results The positive expression of wt-p53 in the retina of the ischemic group and the treated group was statistically significant (P <0.05). Conclusions: Intravitreal injection of wild chrysanthemum injection can inhibit the expression of wt-p53 after retinal ischemia / reperfusion.