目的：研究妊娠高血压综合征（妊高征）的免疫学发病机制。方法：通过检测妊高征患者及正常孕妇蜕膜组织细胞培养上清液中白细胞介素－１（ＩＬ－１）、白细胞介素－２（ＩＬ－２）和肿瘤坏死因子－α（ＴＮＦ－α）的活性，分析蜕膜免疫细胞因子的变化与妊高征之间的关系。结果：与正常孕妇相比，妊高征患者蜕膜组织中ＩＬ－１、ＩＬ－２和ＴＮＦ－α的分泌显著升高。结论：蜕膜组织免疫微环境中细胞因子的改变可能是妊高征发病的机制之一 Objective: To study the immunological pathogenesis of pregnancy induced hypertension (PIH). Methods: The levels of interleukin-1 (IL-1), interleukin-2 (IL-2) and tumor necrosis factor-alpha (TNF- alpha) in the culture supernatant of patients with PIH and normal pregnant women were measured. α) activity, decidual immunocytokine analysis of changes and the relationship between pregnancy-induced hypertension. Results: Compared with normal pregnant women, the secretion of IL-1, IL-2 and TNF-α in decidua of PIH patients was significantly increased. Conclusion: The changes of cytokines in immune microenvironment of decidual tissue may be one of the mechanisms of PIH