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目的:探讨替硝唑联合克林霉素治疗细菌性阴道病的临床疗效。方法:选择我院门诊2016年1月-2017年1月收治的78例细菌性阴道病患者,随机将其分为治疗组和对照组,各39例。治疗组采用口服替硝唑联合外用克林霉素方式治疗,对照组口服替硝唑进行治疗,1个疗程后观察两组患者的疗效及不良反应情况。结果:治疗1个疗程后,治疗组治愈20例,有效18例,无效1例,有效率为97.44%。对照组治愈15例,有效17例,无效7例,有效率为82.05%.两组患者有效率比较,差异具有统计学意义,P<0.05。治疗组中出现2例恶心,3例口苦,1例乏力,不良反应发生率15.38%;对照组出现3例恶心,3例口苦,1例乏力,不良反应发生率17.95%。两组患者不良反应率比较无统计学意义,P>0.05。半年后随访,治疗组复发率为5.13%。对照组复发率为15.38%,两组患者复发率比较有统计学意义,P<0.05。结论:采用替硝唑联合克林霉素治疗细菌性阴道病的临床疗效满意,值得推广应用。
Objective: To investigate the clinical effect of tinidazole combined with clindamycin in the treatment of bacterial vaginosis. Methods: A total of 78 patients with bacterial vaginosis admitted from January 2016 to January 2017 in our hospital were randomly divided into treatment group and control group, with 39 cases in each group. The treatment group was treated with oral tinidazole combined with topical clindamycin, while the control group was treated with tinidazole orally. After one course of treatment, the curative effect and adverse reactions of the two groups were observed. Results: After a course of treatment, 20 cases were cured, 18 cases were effective, 1 case was ineffective, and the effective rate was 97.44%. The control group was cured in 15 cases, effective in 17 cases, ineffective in 7 cases, the effective rate was 82.05% .Comparison of the two groups of effective rates, the difference was statistically significant, P <0.05. There were 2 cases of nausea in the treatment group, 3 cases of mouth pain, 1 case of fatigue and 15.38% of adverse reactions. The control group showed 3 cases of nausea, 3 cases of mouth pain, 1 case of fatigue and 17.95% of adverse reactions. There was no significant difference in adverse reactions between the two groups (P> 0.05). Follow-up after six months, the treatment group relapse rate was 5.13%. The recurrence rate of the control group was 15.38%. The relapse rate of the two groups was statistically significant (P <0.05). Conclusion: The clinical efficacy of tinidazole combined with clindamycin in the treatment of bacterial vaginosis is satisfactory, which is worth popularizing and applying.