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目的探究在难治性肾病综合征(RNS)治疗中联合应用低分子肝素、激素、环磷酰胺的效果。方法 80例RNS患者,将其随机分为实验组(低分子肝素+激素+环磷酰胺)与参照组(激素+环磷酰胺),各40例。对比两组患者的治疗效果以及各指标的变化情况。结果实验组的治疗总有效率显著高于参照组,差异具有统计学意义(P<0.05)。治疗后两组患者的各项指标均较治疗前改善,实验组各指标改善程度优于参照组,差异均具有统计学意义(P<0.05)。结论联合应用低分子肝素、激素、环磷酰胺治疗RNS能够取得较好的治疗效果,值得予以推广。
Objective To explore the effect of combined application of low molecular weight heparin, hormone and cyclophosphamide in the treatment of refractory nephrotic syndrome (RNS). Methods 80 patients with RNS were randomly divided into experimental group (low molecular weight heparin + hormone + cyclophosphamide) and reference group (hormone + cyclophosphamide), 40 in each. Compare the treatment effect of two groups of patients and the change of each index. Results The total effective rate of the experimental group was significantly higher than that of the reference group, the difference was statistically significant (P <0.05). After treatment, the indexes of both groups improved more than before treatment, and the improvement of each index in the experimental group was better than that of the reference group. The differences were statistically significant (P <0.05). Conclusion The combination of low molecular weight heparin, hormone and cyclophosphamide in the treatment of RNS can achieve better therapeutic effect and is worth to be popularized.