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B淋巴细胞刺激因子是肿瘤坏死因子超家族的成员之一,它同自身免疫疾病的发生发展密切相关,BLyS过度表达会促使B淋巴细胞增殖并分泌自身抗体。BLyS也是治疗自身免疫疾病的重要靶点。关于BLyS的调控涉及了许多蛋白。本文主要就G-CSF、TGF-β1、IFN-γ、IL-10和Poly(I:C)等对BLyS的调控作用作一综述。
B lymphocyte stimulating factor is a member of the tumor necrosis factor superfamily. It is closely related to the development of autoimmune diseases. BLyS overexpression will promote the proliferation of B lymphocytes and secrete autoantibodies. BLyS is also an important target for the treatment of autoimmune diseases. There are many proteins involved in the regulation of BLyS. This review focuses on the regulatory effects of G-CSF, TGF-β1, IFN-γ, IL-10 and Poly (I: C) on BLyS.