[目的]评价国产与进口奥美拉唑的临床疗效及安全性。[方法]2006年9月~2007年8月间收治的消化性溃疡出血患者120例,随机分为国产奥美拉唑治疗(国产)组和进口奥美拉唑治疗(进口)组,各60例,均为静脉滴注,40 mg/次,1次/12 h,疗程5 d。[结果]治疗后国产组显效率为80.00%,进口组为83.33%,总有效率分别为96.68%、98.33%,2组疗效比较差异无统计学意义(P>0.05),2组不良反应均轻微。[结论]国产与进口奥美拉唑治疗消化性溃疡出血疗效相当。 [Objective] To evaluate the clinical efficacy and safety of domestic and imported omeprazole. [Method] A total of 120 patients with peptic ulcer bleeding admitted from September 2006 to August 2007 were randomly divided into domestic omeprazole group (domestic group) and imported omeprazole group Cases, are intravenous drip, 40 mg / time, 1/12 h, course of treatment 5 d. [Results] The effective rate of domestic group was 80.00% and that of import group was 83.33%, the total effective rates were 96.68% and 98.33% respectively. There was no significant difference in the curative effect between the two groups (P> 0.05) slight. [Conclusion] Domestic and imported omeprazole have the same effect in the treatment of peptic ulcer bleeding.