肿瘤组织微血管密度(microvessel density,MVD)是采用免疫组织化学技术对肿瘤组织内血管内皮细胞抗原染色标记量化,进行微血管定量,作为反映肿瘤组织内血管生成状况的重要参数,并应用于分析和评估肿瘤的生物学意义。早在1945年Algire等[1]就在动物实验中提出了肿瘤新生血管形成 The microvessel density (MVD) of tumor tissue was quantified by immunohistochemical staining of the vascular endothelial cell antigen in the tumor tissue, and the microvessel volume was quantified as an important parameter reflecting the angiogenesis status in the tumor tissue, and used for analysis and evaluation The biological significance of tumor. As early as 1945, Algire et al [1] proposed tumor neovascularization in animal experiments