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目的分析人乳头瘤病毒(HPV)基因型在广州市番禺区不同年龄段的户籍妇女中的感染分布情况及其与其他地区人群的差异性,并探讨HPV在妇女宫颈病变中的型别分布特征。方法广州市番禺区内9 989例妇女采用基质辅助激光解析电离飞行时间质谱技术(MALDI-TOF-MS)对其宫颈脱落细胞进行HPV检测分析,并对HPV阳性人群进行液基细胞学检测(TCT)及阴道镜活体组织检查(活检)。结果广州市番禺区989例妇女HPV总感染率为8.33%,HPV感染在各个年龄段中检出率差异无统计学意义(χ2=4.83,P>0.05)。HPV感染以HPV 52、16、58、51为主要感染型别,且复合感染随着病变程度的增加而增加。HPV感染者伴TCT结果为意义不明的非典型鳞状上皮细胞(ASC-US)程度以上的受检者行阴道镜检查及活检92例,发现1例原位癌患者HPV感染类型为二重感染,感染型别为HPV 31及33,癌前病变及癌症的发病率为0.17%。结论HPV在年龄的感染率分布与其他地区的分布一致呈U型分布,广州市番禺区妇女的宫颈癌前病变及癌症发病率远低于其农村妇女。
Objective To analyze the distribution of human papillomavirus (HPV) genotypes in household women of different ages in Panyu District of Guangzhou City and their differences with other regions of the population and to explore the type distribution of HPV in women with cervical lesions . Methods Nine hundred and ninety-nine women in Panyu District of Guangzhou City were tested for HPV by cervical cancer using matrix-assisted laser desorption / ionization time of flight mass spectrometry (MALDI-TOF-MS), and liquid-based cytology ) And colposcopic biopsy (biopsy). Results The prevalence of HPV in 989 women in Panyu district of Guangzhou was 8.33%. There was no significant difference in the detection rate of HPV among all age groups (χ2 = 4.83, P> 0.05). HPV infection with HPV 52,16,58,51 as the main infection type, and the compound infection increased with the degree of lesion. HPV infection with TCT results of atypical squamous cells of unknown significance (ASC-US) above the level of subjects underwent colposcopy and biopsy in 92 cases and found that one case of HPV in situ cancer patients with type of double infection , The infection type is HPV 31 and 33, the incidence of precancerous lesions and cancer is 0.17%. Conclusion The distribution of HPV infection in age is consistent with that of other regions. The incidence of cervical precancerous lesions and cancer in Panyu District of Guangzhou is much lower than that of rural women.