精原干细胞是具有自我更新和多向分化潜能等特性的多能干细胞 ,可在自身基因和 /或外来信号调节下最终分化为精子 ,对其研究近年来倍受关注。本文介绍了精原干细胞的富集、初次分选技术 ,增殖调控因子以及移植技术的研究进展。 Spermatogonial stem cells (Spermatogonial stem cells) are pluripotent stem cells that have the potential of self-renewal and multidirectional differentiation. They can eventually differentiate into spermatozoa under the regulation of their own genes and / or extrinsic signals, and their research has drawn much attention in recent years. This article describes the research progress of spermatogonial stem cells enrichment, primary sorting, proliferation regulators and transplantation.