论文部分内容阅读
目的:研究TORCH综合征与自然流产的相关性。方法:采用酶联免疫(ELISA)对1100例早期自然流产妇女(孕3个月以内)的血清进行弓形体(T)-IgM,风疹病毒(R)-IgM及巨细胞病毒(C)-IgM的检测,并和658例正常早期妊娠妇女作比较,探讨孕妇TORCH感染与流产的关系。结果:早期自然流产妇女血清的T-IgM阳性率为18.3%;R-IgM阳性率为6.3%;C-IgM阳性率为13.8%。正常对照组的T-IgM阳性率1.2%;R-IgM为1.36%;C-IgM阳性率为3.6%,差异具有统计学意义(P<0.01)。结论:TORCH是一组广泛传播的病源微生物。孕妇由于促性腺激素、孕酮、雌激素水平增高,NK细胞活力下降,使孕妇免疫力低下,对不良影响最敏感,TORCH感染呈上升趋势,易发生原发感染和复发感染。TORCH中的B弓形体、风疹病毒和巨细胞病毒也是胎儿感染的最常见,危害最大的一组病原体。T、R、C都可通过胎盘、产道或母乳传染给胎儿或新生儿。胎儿感染可导致流产、早产、死胎或胎儿生长迟缓和畸形;新生儿感染可造成智力障碍以及瘫痪、失明、失聪等严重后遗症。因此把T-IgM、R-IgM、C-IgM的检测做为妊娠妇女的常规检测项目是必要的。
Objective: To study the correlation between TORCH syndrome and spontaneous abortion. Methods: The serums of Toxoplasma gondii (T) -IgM, rubella virus (R) -IgM and cytomegalovirus (C) -IgM were detected by enzyme linked immunosorbent assay (ELISA) in 1100 women with spontaneous abortion in their first trimester , And compared with 658 normal early pregnant women to explore the relationship between TORCH infection and abortion in pregnant women. Results: The positive rate of T-IgM in early spontaneous abortion women was 18.3%; the positive rate of R-IgM was 6.3%; the positive rate of C-IgM was 13.8%. The positive rate of T-IgM in normal control group was 1.2%; the R-IgM was 1.36%; the positive rate of C-IgM was 3.6%, the difference was statistically significant (P <0.01). Conclusion: TORCH is a group of widely spread pathogenic microorganisms. Pregnant women due to gonadotropin, progesterone, estrogen levels increased, NK cell activity decreased, so that pregnant women with low immunity, the most sensitive to adverse effects, TORCH infection is on the rise, prone to primary infection and recurrent infections. The B toxoplasma, rubella virus and cytomegalovirus in TORCH are also the most common and damaging group of pathogens in fetal infections. T, R, C can be transmitted through the placenta, birth canal or breast milk to the fetus or newborn. Fetal infection can cause miscarriage, premature birth, stillbirth or fetal growth retardation and deformity; neonatal infection can cause mental retardation and serious complications such as paralysis, blindness, deafness and so on. Therefore, the T-IgM, R-IgM, C-IgM detection as a routine test of pregnant women is necessary.