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目的研究白蛋白联合间断性蓝光照射治疗足月新生儿中重度黄疸的效果。方法选取2013年9月至2014年9月封丘县人民医院收治的足月新生儿中重度黄疸患儿98例,按照随机数字表法分为对照组和观察组,每组49例。所有患儿均采用新生儿黄疸治疗仪行蓝光间断照射治疗,照射治疗4 d,观察组在此基础上给予白蛋白静脉滴注,持续给药5 d后观察对比两组患儿血清胆红素相关指标变化情况及安全性。结果两组患儿治疗前血清胆红素相关指标水平比较差异未见统计学意义(P>0.05);两组患儿治疗后相关指标均显著下降(P<0.05);观察组指标下降程度较对照组显著,差异有统计学意义(P<0.05);两组患儿均出现了轻微不良反应,治疗结束后症状消失,其不良发应发生率低,组间比较差异未见统计学意义(P>0.05)。结论对足月新生儿中重度黄疸行白蛋白联合间断性蓝光照射治疗,疗效好,安全性高,值得临床推广。
Objective To study the effect of albumin combined with intermittent blue light irradiation on term neonates with moderate-severe jaundice. Methods A total of 98 infants with moderate-severe jaundice in full-term neonates admitted to Fengqiu County People’s Hospital from September 2013 to September 2014 were randomly divided into control group and observation group with 49 cases in each group. All children were treated with neonatal jaundice treatment instrument intermittent blue light irradiation treatment for 4 days, the observation group was given albumin intravenous infusion on this basis, continuous administration of 5 d after the observation of two groups of children with serum bilirubin Changes in relevant indicators and safety. Results The levels of serum bilirubin in the two groups before treatment did not reach statistical significance (P> 0.05). The relative indexes of both groups were significantly decreased after treatment (P <0.05) There was significant difference between the two groups (P <0.05). There was slight adverse reaction in both groups. After the treatment, the symptoms disappeared and the incidence of adverse reactions was low. There was no significant difference between the two groups P> 0.05). Conclusion The treatment of moderate-severe jaundice in term neonates with albumin combined with intermittent blue light irradiation has good curative effect and high safety, which is worthy of clinical promotion.