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目的探讨泌尿男生殖系多原发恶性肿瘤(MPMN)的诊断和手术治疗的临床疗效。方法对63例泌尿男生殖系MPMN患者的临床资料进行回顾性分析,所有患者均行手术治疗,其中29例行根治性膀胱前列腺全切,13例行经尿道膀胱癌电切术(TURBT)+经尿道前列腺电切术(TURP),13例行膀胱部分切除术+化疗和内分泌治疗,4例行根治性肾切除+内分泌治疗,2例行肾癌治疗+TURBT,2例行肾癌根治+根治性膀胱全切。结果经病理诊断,前列腺癌59例,膀胱癌55例,肾透明细胞癌6例,乳头状肾癌2例;手术治疗后随访10~48个月,37例平均生存26个月,26例无瘤生存。结论泌尿男生殖系是MPMN好发部位,以前列腺癌、膀胱癌最为多见,应做到早期发现、诊断,并遵循综合、个体化的治疗原则,采用以根治性手术治疗为主的综合治疗,这对MPMN患者的预后及生存有着重要的临床意义。
Objective To investigate the clinical efficacy of diagnosis and surgical treatment of multiple malignant tumors of the male genitourinary tract (MPMN). Methods Retrospective analysis was performed on the clinical data of 63 MPMN patients with genitourinary tract urinary tract infection. All patients underwent surgical treatment. Twenty-nine patients underwent radical prostatectomy and 13 underwent transurethral resection of bladder cancer (TURBT) + Transurethral resection of the prostate (TURP), partial cystectomy in 13 cases, chemotherapy and endocrine therapy in 4 cases, radical nephrectomy + endocrine therapy in 4 cases, TURBT in 2 cases and radical nephrectomy in 2 cases. Radical bladder full cut. Results The pathological diagnosis showed that 59 cases of prostate cancer, 55 cases of bladder cancer, 6 cases of clear cell renal cell carcinoma and 2 cases of papillary renal cell carcinoma. After the operation was followed up for 10 ~ 48 months, 37 cases survived for an average of 26 months, 26 cases had no Tumor survival. Conclusions Urinary male reproductive system is a predilection site for MPMN. Prostate cancer and bladder cancer are the most common and should be detected and diagnosed early, and follow the principle of comprehensive and individualized treatment. Comprehensive treatment based on radical surgical treatment , Which has an important clinical significance for the prognosis and survival of MPMN patients.