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The relationship between vitamin D metabolic enzymes (CYP27A1,CYP27B1,and CYP24A1) and vitamin D receptor (VDR) in non-melanoma skin cancer (NMSC) development and progression is not entirely clear.However,several clinical studies and in vitro reports indicate a connection between vitamin D metabolic key players and NMSCs by demonstrating inhibitory effects on tumor cells and positive effects in skin cancer prevention of higher circulatory 25-hydroxyvitamin D [1].