CD59是一种通过糖基磷脂酰肌醇(GPI)锚定于细胞膜表面的补体调节蛋白,通过干扰C8和C9结合,在补体系统激活后的酶级联反应终末阶段抑制膜攻击复合物(MAC)的形成,进而保护宿主细胞。CD59的异常表达可引起多种自身免疫性疾病,在肿瘤细胞表面的高表达,则与单克隆抗体类药物治疗时的耐药密切相关。现就近年来CD59的功能及表达调控研究进展进行综述。 CD59, a complement regulatory protein anchored to the cell membrane surface by glycosylphosphatidylinositol (GPI), inhibits the membrane attack complex at the terminal stage of the enzyme cascade after activation of the complement system by interfering with the binding of C8 and C9 MAC) formation, which in turn protects the host cell. Abnormal expression of CD59 can cause a variety of autoimmune diseases, high expression on the surface of tumor cells, and the monoclonal antibody drug resistance is closely related. In recent years, the function and expression of CD59 regulatory progress are reviewed.