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目的探讨帕金森病（ＰＤ）发病的危险因素。方法利用病例对照研究方法对１００例ＰＤ患者和１００例年龄及性别相匹配的对照组进行分析，并对７２例ＰＤ和６６例对照者的载脂蛋白Ｅ（ａｐｏＥ）基因型进行检测。结果发现引起ＰＤ发病的危险因素包括不良环境暴露、幼年期的居住地、脑外伤、阳性家族史及农业劳动等；同时发现ａｐｏＥ等位基因频率在ＰＤ和本研究的对照组间分布无显著性差异。结论本研究支持在ＰＤ发病机制中环境因素比遗传因素可能更为重要。
Objective To investigate the risk factors of Parkinson’s disease (PD). Methods A case-control study was performed on 100 PD patients and 100 age- and sex-matched control subjects. The apoE genotypes of 72 patients with PD and 66 controls were analyzed. The risk factors of PD were found to include adverse environmental exposure, residence in juvenile period, traumatic brain injury, positive family history and agricultural labor. At the same time, there was no significant difference in the distribution of apoE allele between PD and the control group difference. Conclusion This study supports the fact that environmental factors may be more important than genetic factors in the pathogenesis of PD.