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本文报道了51个协作中心,有848例十二指肠溃疡病人参加的用呋喃硝胺或甲腈咪胍预防溃疡复发的比较试验。病人和方法本试验采用双盲随机比较法。243例睡前给呋喃硝胺150mg,241例睡前给甲腈咪胍400mg,维持治疗1年,以预防新近已愈合的十二指肠溃疡复发。指定专人在试验前和试验后4、8、12个月做内窥镜检查。本组病人均为积极治疗后经内窥镜证实十二指肠溃疡已愈合的门诊病人。活动性胃溃疡、1年内作过胃手术、胃酸低分泌状态和有明显
This paper reports 51 cooperating centers, 848 cases of duodenal ulcer patients participated in the trial of furanitamide or cimetidine to prevent ulcer recurrence. Patients and Methods This trial used a double-blind randomized comparison. 243 patients were given nitrofurantoin 150mg before bedtime and 241 patients were given nitrocellulose 400mg before going to bed for one year to prevent the recurrence of the recently healed duodenal ulcer. Designate specialists to do endoscopy 4 and 8 months before and after the test. This group of patients were positive after treatment confirmed by endoscopy duodenal ulcers have been cured out-patients. Active gastric ulcer, gastric surgery within 1 year, gastric acid secretion and have obvious