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“君臣佐使”是中药复方配伍的基本结构,是在中医药学理论指导下派生而来的用以解释传统复方作用机制的重要原则。中药复方药效具有多靶点的特性,用不同的药效指标评价复方配伍机制并不完全一致。结构方程模型可将复方各药效指标整合为综合药效,并基于研究者的先验知识预先设定因子间的依赖关系,不仅能够判别各因子之间的路径系数,还能对整体模型进行拟合和判断。文章首先介绍复方配伍的基本内容,然后阐述了应用结构方程(SEM)建模分析步骤,最后基于AMOS软件,以苓桂术甘汤为例展示其在复方配伍机制研究中的应用。
“Monarch conciliation makes ” is the basic structure of compatibility of traditional Chinese medicine compound is an important principle derived from the guidance of traditional Chinese medicine theory to explain the mechanism of traditional compound. The efficacy of traditional Chinese medicine compound has multi-target characteristics, evaluation of compound compatibility mechanism with different efficacy indicators is not exactly the same. The structural equation model can integrate each efficacy index of the compound into the comprehensive efficacy, and predetermine the dependence between factors based on the prior knowledge of the researcher, which not only can determine the path coefficient between the various factors, but also can carry out the overall model Fit and judge. The article first introduces the basic content of compound compatibility, and then expounds the application of structural equation (SEM) modeling and analysis steps, and finally based on the AMOS software to Lingguizhugan Tang as an example to demonstrate its application in the study of compound compatibility mechanism.