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60年代末开始了人类骨髓移植的新纪元。当时已可用组织配型技术挑选HLA相同的患者的同胞作为供体。1978年,人们已认识到骨髓移植可用于治疗两种非恶性疾病,即联合免疫缺陷症(此病因免疫功能抑制易于接受移植物)和再生障碍性贫血(此病的骨髓床空虚,移植物有着床生长的场所)。Wiskott-Aldrich综合征则不然,其骨髓细胞成分异常,其免疫缺陷尚不容异体移植物生长。Parkman等全身放射照射以破坏其异常骨髓细胞,为骨髓移植提供生长的地方,并抑制患者的免疫排斥反应;另一种免疫抑
The new era of human bone marrow transplantation began in the late 1960s. At that time, siblings of HLA-identical patients were selected as donors by tissue typing techniques. In 1978, it was recognized that bone marrow transplantation can be used to treat two non-malignant diseases, namely, combined immunodeficiency (which is immunocompromised to be receptive to grafts) and aplastic anemia (the bed is empty, the graft has Bed growth place). Wiskott-Aldrich syndrome is not the case, the abnormal bone marrow cells, its immune deficiency is not tolerated body graft growth. Parkman and other whole body radiation to destroy the abnormal bone marrow cells, provide a place for bone marrow transplantation and inhibit the patient’s immune rejection; another immunosuppression