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目的 评估癌旁胆管反应与肝癌患者的临床病理资料间的关系.方法 收集2010年3月—2015年8月苏州市立医院原发性肝细胞癌根治性手术后病理标本68 例.随访结束时间为2017年12月.运用免疫组织化学方法检测癌旁胆管反应情况.整理肝细胞癌患者的临床及随访资料,分析癌旁胆管反应与肝细胞癌患者临床病理特征的关系.结果 癌旁胆管反应的程度与肝癌患者血清AFP水平(P＝0.036)、血清ALT(P＝0.016)、血清HBsAg (+)(P＝0.004)、肿瘤包膜(P＝0.014)、肿瘤个数(P＝0.009)、镜下血管侵犯(P＝0.029)、早期复发(P＝0.032)、BCLC分期(P＝0.007)和TNM分期(P＝0.012)显著相关.结论 癌旁组织中胆管反应的程度与肝细胞癌患者临床病理中肿瘤强侵袭性指标显著相关,癌旁胆管反应高的肿瘤表现出更强的侵袭性.“,”Objective To evaluate the peritumoral ductular reaction (DR) in hepatocellular carcinoma (HCC), and its relationship with the clinicopathological features. Methods The clinicopathological features and DR were analyzed in 68 HCC patients who received curative hepatectomy at the Suzhou Municipal Hospital from March 2010 to August 2015. Follow-up was completed in December 2017. DR was performed by immunohistochemical analysis on peritumoral tissue sections. Relationship between peritumoral DR and clinicopathological features was performed by statistical analysis. Results Increased DR correlated with elevated serum ALT (P＝0.016), AFP (P＝0.036) and HBsAg (+) (P＝0.004). Increased DR also correlated with multiple nodules (P＝0.009), absence of tumor capsule (P＝0.014), severe microscopic vascular invasion (P＝0.029), early recurrence (P＝0.032), with advanced BCLC stage (P＝0.007) and TNM stage (P＝0.012). Conclusion Peritumoral DR significantly correlated with aggressive clinicopathological features. It plays a critical role in the aggressiveness of HCC.