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速尿是一种非常有效的利尿剂,可引起各种不良反应,主要是电解质紊乱及血容量减少,但其发生率及诱发因素尚未阐明。本文报道美国、加拿大、新西兰等地协作研究2,367例应用速尿治疗的住院患者的不良反应。二分之一以上患者的年龄超过69岁,入院时有中度或严重肾功能衰竭、血尿素氮在50毫克/100毫升或以上者占11.2％。半数以上患者的出院诊断为心血管疾病;充血性心力衰竭是速尿治疗的最常见指征。速尿应用的剂量范围很大;21.4％患者的每日平均量大于55毫克,29％患者的速尿总量大于
Furosemide is a very effective diuretic, can cause a variety of adverse reactions, mainly electrolyte imbalance and decreased blood volume, but its incidence and induced factors have not yet been elucidated. This article reports the collaborative study of 2,367 hospitalized patients with furosemide treatment in the United States, Canada, New Zealand and other places. More than one in two patients is over 69 years of age with moderate or severe renal failure at admission and 11.2% with a blood urea nitrogen level of 50 mg / 100 mL or more. Discharge from more than half of patients is diagnosed with cardiovascular disease; congestive heart failure is the most common indication for furosemide treatment. The range of doses used for furosemide was large; 21.4% of patients had an average daily dose of greater than 55 mg, and 29% of patients had greater total furosemide