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在口腔颌面部恶性肿瘤中,鳞癌约占80%以上。博莱霉素(BLM)作为治疗口腔颌面部鳞癌的主要药物之一,在如何进一步提高它对鳞癌的疗效方面,已愈来愈引起人们的关注。到目前为止,国内外有关高压氧(HBO)合并放疗或与化学抗癌药物联合应用已进行了大量的研究。本文将根据目前国内外有关这方面的研究,以 BLM 为主,试从以下几个方面综述高压氧—化学抗癌药物在口腔颌面部鳞癌治疗中的应用。一、高压氧-化疗药物对癌细胞的作用1.对肿瘤细胞核酸的影响:Ishida 等的
In oral and maxillofacial malignancies, squamous cell carcinoma accounts for more than 80%. BLM is one of the main drugs for the treatment of squamous cell carcinoma of oral and maxillofacial region. It has attracted more and more attention on how to further improve its curative effect on squamous cell carcinoma. So far, a great deal of research has been done at home and abroad on the combined use of hyperbaric oxygen (HBO) combined radiotherapy or chemical anticancer drugs. This article will be based on the current research in this area at home and abroad, mainly BLM, try to summarize the following aspects of the use of hyperbaric oxygen - chemical anticancer drugs in the treatment of oral and maxillofacial squamous cell carcinoma. I. Effects of hyperbaric oxygen-chemotherapy drugs on cancer cells 1. Effects on tumor cell nucleic acid: Ishida et al.